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Phenotypes Associated with This Genotype
Genotype
MGI:4461250
cn1
Allelic
Composition
Ctnnb1tm4Wbm/Ctnnb1tm4Wbm
Gli1tm3(cre/ERT2)Alj/Gli1+
Genetic
Background
involves: 129P2/OlaHsd * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm4Wbm mutation (1 available); any Ctnnb1 mutation (49 available)
Gli1tm3(cre/ERT2)Alj mutation (2 available); any Gli1 mutation (50 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• 40% of tamoxifen-treated male mice fail to develop a proper prepuce and ventral midline formation unlike wild-type mice
• however, development of female genital tracts is normal
• 40% of tamoxifen-treated male mice fail to develop a proper prepuce unlike wild-type mice

renal/urinary system
• 40% of tamoxifen-treated male mice fail to develop a proper prepuce unlike wild-type mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory