Phenotypes Associated with This Genotype

Genotype
MGI:4461401

• Allelic Composition: Dp(10Prmt2-Pdxk)2Yey/0; Dp(16Lipi-Zbtb21)1Yey/0; Dp(17Abcg1-Rrp1b)3Yey/0
• Genetic Background: B6.129S7-Dp(10Prmt2-Pdxk)2Yey Dp(16Lipi-Zbtb21)1Yey Dp(17Abcg1-Rrp1b)3Yey

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased survivor rate ( J:161325 )

• mice with hydrocephaly die around 6 to 8 weeks of age

premature death ( J:161325 )

• mice with hydrocephaly die around 6 to 8 weeks of age

neonatal lethality, incomplete penetrance ( J:161325 )

• about 26% die soon after birth

behavior/neurological

impaired contextual conditioning behavior ( J:161325 )

• freeze significantly less when returned to the test chamber 24 h or 72 h after initial training and foot shock

abnormal spatial learning ( J:161325 )

• display a longer latency and a longer path length to reach the hidden platform in a Morris water maze

abnormal spatial reference memory ( J:161325 )

• in a Morris water maze probe test mice spend less time in the target quadrant

impaired swimming ( J:161325 )

• decrease in swimming speed

decreased grip strength ( J:161325 )

• in all limbs

nervous system

obstructive hydrocephaly ( J:161325 )

• seen in about 6.5% of mice, associated with aqueductal stenosis

cerebral aqueductal stenosis ( J:161325 )

dilated lateral ventricle ( J:161325 )

• in mice with hydrocephaly

reduced long-term potentiation ( J:161325 )

• in the hippocampus

cardiovascular system

abnormal heart morphology ( J:161325 )

• display heart defects at a similar frequency to mice hemizygous for Dp(16Lipi-Zfp295)1Yey alone

reproductive system

reproductive system phenotype ( J:161325 )

N • unlike mice carrying Ts(17<16>)65Dn , no reproductive impairment is seen in mice even when put on an inbred background

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Down syndrome		DOID:14250	OMIM:190685	J:161325