Phenotypes Associated with This Genotype

Genotype
MGI:4462257

• Allelic Composition: Kit^W-sh/Kit^W-sh; Lyn^tm1Ard/Lyn^tm1Ard
• Genetic Background: involves: 101 * 129P2/OlaHsd * C3H/HeH

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

increased basophil cell number ( J:161523 )

decreased B cell number ( J:161523 )

• in the bone marrow, blood and spleen

increased IgA level ( J:161523 )

increased IgE level ( J:161523 )

increased IgG2b level ( J:161523 )

increased IgM level ( J:161523 )

immune system

increased basophil cell number ( J:161523 )

decreased B cell number ( J:161523 )

• in the bone marrow, blood and spleen

increased IgA level ( J:161523 )

increased IgE level ( J:161523 )

increased IgG2b level ( J:161523 )

increased IgM level ( J:161523 )

abnormal circulating complement protein level ( J:161523 )

• increased circulating immune complexes reactive to complement component 1 q

increased anti-nuclear antigen antibody level ( J:161523 )

• of IgE isotype

increased anti-double stranded DNA antibody level ( J:161523 )

• of IgE isotype

glomerulonephritis ( J:161523 )

homeostasis/metabolism

abnormal circulating complement protein level ( J:161523 )

• increased circulating immune complexes reactive to complement component 1 q

albuminuria ( J:161523 )

• elevated albumin-to-creatinine ratio

renal/urinary system

albuminuria ( J:161523 )

• elevated albumin-to-creatinine ratio

glomerulonephritis ( J:161523 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
systemic lupus erythematosus		DOID:9074	OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420	J:161523