Analysis Tools
hematopoietic system
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• additional disruption of the gamma adducin gene does not exacerbate the phenotype of the beta adducin knockout and the changes in hematological values, altered red blood cell shapes and size, reticulocytosis, decreased hematocrit, and increased red blood cell fragility are the same, although the alpha adducin levels in red blood cell membranes is reduced to an almost undetectable level and the level in brain and spleen is reduced to half normal levels
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• the increase in red blood cell fragility as assessed by osmotic lysis and ektacytometry is the same as in beta adducin knockouts
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