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Phenotypes Associated with This Genotype
Genotype
MGI:4818270
cn7
Allelic
Composition
Grb2tm1.1Hua/Grb2tm1.1Hua
Tg(Lck-cre)1Jtak/0
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grb2tm1.1Hua mutation (0 available); any Grb2 mutation (43 available)
Tg(Lck-cre)1Jtak mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• slightly in the thymus and lymph nodes
• maturation of double positive thymocytes to single positive thymocytes is impaired compared to in wild-type mice
• mice exhibit a marked decrease in CD4+ T cells in the thymus compared with wild-type mice
• peripheral CD4+ T cells in the spleen and lymph node are decreased compared to in wild-type mice
• mice exhibit a moderate decrease in CD8+ T cells in the thymus compared with wild-type mice
• peripheral CD8+ T cells in the spleen and lymph node are decreased compared to in wild-type mice

hematopoietic system
• slightly in the thymus and lymph nodes
• maturation of double positive thymocytes to single positive thymocytes is impaired compared to in wild-type mice
• mice exhibit a marked decrease in CD4+ T cells in the thymus compared with wild-type mice
• peripheral CD4+ T cells in the spleen and lymph node are decreased compared to in wild-type mice
• mice exhibit a moderate decrease in CD8+ T cells in the thymus compared with wild-type mice
• peripheral CD8+ T cells in the spleen and lymph node are decreased compared to in wild-type mice

endocrine/exocrine glands
• slightly in the thymus and lymph nodes


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory