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Phenotypes Associated with This Genotype
Genotype
MGI:4818271
cn2
Allelic
Composition		 Grb2tm1.1Hua/Grb2tm1.1Hua
Tg(DO11.10)10Dlo/0
Tg(Lck-cre)1Jtak/0
Genetic
Background		 involves: 129 * BALB/c * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grb2tm1.1Hua mutation (0 available); any Grb2 mutation (43 available)
Tg(DO11.10)10Dlo mutation (7 available)
Tg(Lck-cre)1Jtak mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell differentiation ( J:161294 )
• positive selection of CD4+ cells is severely impaired compared to in DO11.10 TCR control mice

hematopoietic system
abnormal T cell differentiation ( J:161294 )
• positive selection of CD4+ cells is severely impaired compared to in DO11.10 TCR control mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory