Phenotypes for H2az2 Lmx1b MGI:4818571 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Lmx1b^tm1Rjo/Lmx1b^tm4.1Rjo H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2^{Tg(Wnt1-cre)11Rth} mutation (2 available); any H2az2 mutation (27 available)
Lmx1b^tm1Rjo mutation (0 available); any Lmx1b mutation (16 available)
Lmx1b^tm4.1Rjo mutation (1 available); any Lmx1b mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

ciliary body hypoplasia ( J:161793 )

• hypoplastic at E18.5

iris stroma hypoplasia ( J:161793 )

• at E18.5

irregularly shaped pupil ( J:161793 )

• at E18.5

• less severe than in Lmxb1^tm1Rjo homozygous mice

abnormal cornea morphology ( J:161793 )

cornea vascularization ( J:161793 )

• blood vessels are present in the corneal stroma

abnormal cornea stroma morphology ( J:161793 )

• less dense

• blood vessels are present

decreased eye anterior chamber depth ( J:161793 )

• decrease in anterior chamber depth

abnormal lens epithelium morphology ( J:161793 )

• thickened

microphthalmia ( J:161793 )

• at E18.5

cardiovascular system

cornea vascularization ( J:161793 )

• blood vessels are present in the corneal stroma

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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