Phenotypes for Lmx1b Pitx2 MGI:4818572 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Lmx1b^tm1Rjo/Lmx1b^tm4.1Rjo Pitx2^tm4(cre)Jfm/Pitx2⁺
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmx1b^tm1Rjo mutation (0 available); any Lmx1b mutation (16 available)
Lmx1b^tm4.1Rjo mutation (1 available); any Lmx1b mutation (16 available)
Pitx2^tm4(cre)Jfm mutation (1 available); any Pitx2 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal intraocular muscle morphology ( J:161793 )

• expression analysis indicates the absence of sphincter and dilator muscles in the iris

abnormal iridocorneal angle ( J:161793 )

• angle closure

absent trabecular meshwork ( J:161793 )

absent ciliary body ( J:161793 )

• not detectable

irregularly shaped pupil ( J:161793 )

• at P13

iris hypoplasia ( J:161793 )

abnormal cornea morphology ( J:161793 )

abnormal cornea endothelium morphology ( J:161793 )

• decrease in the amount of corneal endothelial tissue

cornea opacity ( J:161793 )

• at P13

abnormal lens morphology ( J:161793 )

abnormal lens epithelium morphology ( J:161793 )

• thickened

small lens ( J:161793 )

• about 20% smaller relative to overall eye size

microphthalmia ( J:161793 )

• in about 25% of mice at 3 weeks of age

muscle

abnormal intraocular muscle morphology ( J:161793 )

• expression analysis indicates the absence of sphincter and dilator muscles in the iris

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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