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Phenotypes Associated with This Genotype
Genotype
MGI:4818573
cn2
Allelic
Composition
Lmx1btm1Rjo/Lmx1btm4.1Rjo
Tg(CAG-cre/Esr1*)5Amc/0
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmx1btm1Rjo mutation (0 available); any Lmx1b mutation (16 available)
Lmx1btm4.1Rjo mutation (1 available); any Lmx1b mutation (16 available)
Tg(CAG-cre/Esr1*)5Amc mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• sparsely distributed corneal keratocytes, disorganized collagen fibrils, and wavy lamellae by 4 weeks after tamoxifen treatment
• by 4 weeks after tamoxifen treatment
• thinner by 4 weeks after tamoxifen treatment
• corneas become cloudy by 4 weeks after tamoxifen treatment

renal/urinary system
• dilated tubules filled with eosinophilic material are seen after tamoxifen treatment
• a severe degenerative phenotype with dilated tubules filled with eosinophilic material develops after tamoxifen treatment
• develops after tamoxifen treatment

behavior/neurological
• develops several weeks after tamoxifen treatment

cardiovascular system
• by 4 weeks after tamoxifen treatment


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory