Analysis Tools
skeleton
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• without tamoxifen treatment, mice exhibit multiple hereditary exostose-like skeletal defects unlike wild-type mice
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• 92% of mice exhibit bowing of the radius and subluxation/dislocation of the radial head unlike wild-type mice
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bowed radius
(
J:161395
)
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• 92% of mice exhibit bowing of the radius
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• at P14, mice exhibit an increase in the width of the distal radius compared to wild-type mice
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• at P14, mice exhibit an increase in the width of the distal ulna compared to wild-type mice
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• without tamoxifen treatment, all mice develop osteochondroma in the humerus, radius, ulna, digits, femur, tibia, fibula, vertebrae, and rib bones unlike wild-type mice
• at P7 to P28 in the ribs
• at P14 in the distal femur
• osteochondromas resemble ectopic growth plates rather than true neoplasm
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• mice exhibit bony protrusions with a cartilage cap in the wrist, fibula, shoulder, and rib unlike wild-type mice
• at P14, mice exhibit exostosis unlike wild-type mice
• at P28, mice exhibit multiple protrusions closely resembling osteochondroma unlike in wild-type mice
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• mice exhibit mild abnormalities of the joint cartilage unlike wild-type mice
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• at P14,formation of cartilage occurs in abnormal location compared to in wild-type mice
• at P21, mice exhibit overgrowth and deformity of the cartilage compared with wild-type mice and small cartilaginous islands for in the epiphysis
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• mild
• at P21, mice exhibit small cartilaginous islands for in the epiphysis unlike in wild-type mice
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neoplasm
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• without tamoxifen treatment, all mice develop osteochondroma in the humerus, radius, ulna, digits, femur, tibia, fibula, vertebrae, and rib bones unlike wild-type mice
• at P7 to P28 in the ribs
• at P14 in the distal femur
• osteochondromas resemble ectopic growth plates rather than true neoplasm
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growth/size/body
limbs/digits/tail
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• mice exhibit bowing of the forearm unlike wild-type mice
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|
• 92% of mice exhibit bowing of the radius and subluxation/dislocation of the radial head unlike wild-type mice
|
bowed radius
(
J:161395
)
|
• 92% of mice exhibit bowing of the radius
|
|
• at P14, mice exhibit an increase in the width of the distal radius compared to wild-type mice
|
|
• at P14, mice exhibit an increase in the width of the distal ulna compared to wild-type mice
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| hereditary multiple exostoses | DOID:206 |
OMIM:133700 OMIM:133701 OMIM:600209 |
J:161395 | |
