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Phenotypes Associated with This Genotype
Genotype
MGI:4818940
cn3
Allelic
Composition		 Gt(ROSA)26Sortm1Sho/0
Itga5tm2Hyn/Itga5tm1Hyn
Itgavtm1Hyn/Itgavtm2Hyn
Tg(Tek-cre)1Ywa/0
Genetic
Background		 involves: 129 * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sho mutation (4 available); any Gt(ROSA)26Sor mutation (1026 available)
Itga5tm1Hyn mutation (1 available); any Itga5 mutation (47 available)
Itga5tm2Hyn mutation (2 available); any Itga5 mutation (47 available)
Itgavtm1Hyn mutation (1 available); any Itgav mutation (53 available)
Itgavtm2Hyn mutation (2 available); any Itgav mutation (53 available)
Tg(Tek-cre)1Ywa mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality throughout fetal growth and development, complete penetrance ( J:161850 )
• die at E14.5 of severe dorsal edema and sometimes hemorrhage

cardiovascular system
vascular ring ( J:161850 )
• aorta vascular ring
abnormal ascending aorta morphology ( J:161850 )
• absent ascending aorta
patent ductus arteriosus ( J:161850 )
• in one of two surviving mice
ventricular septal defect ( J:161850 )
• ventricular septation defects

cellular
patent ductus arteriosus ( J:161850 )
• in one of two surviving mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory