Phenotypes Associated with This Genotype

Genotype
MGI:4818943

• Allelic Composition: Tg(CD2-Stat6*V625A*T626A)78Mhk/0
• Genetic Background: involves: C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

excessive scratching ( J:160119 )

• resulting in alopecia on the face, back, and other areas

homeostasis/metabolism

impaired skin barrier function ( J:160119 )

• 10 days after retinoic acid treatment, mice exhibit a 4-fold elevation in transepithelial water loss unlike similarly treated wild-type mice

immune system

dermatitis ( J:160119 )

• mice develop skin inflammation that is similar to atopic dermatitis unlike wild-type mice

integument

impaired skin barrier function ( J:160119 )

• 10 days after retinoic acid treatment, mice exhibit a 4-fold elevation in transepithelial water loss unlike similarly treated wild-type mice

dermatitis ( J:160119 )

• mice develop skin inflammation that is similar to atopic dermatitis unlike wild-type mice

alopecia ( J:160119 )

• on the face, back, and other areas secondary to excessive scratching

mixed cellular infiltration to dermis ( J:160119 )

• eosinophils and lymphocytes

thick dermal layer ( J:160119 )

thick epidermis ( J:160119 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
atopic dermatitis		DOID:3310	OMIM:603165 OMIM:PS603165	J:160119