Phenotypes Associated with This Genotype

Genotype
MGI:4818968

• Allelic Composition: Tg(KRT5-AR)191Cct/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:159989 )

• male mice exhibit gray hair in the inguinal region unlike wild-type mice

integument

abnormal coat/hair pigmentation ( J:159989 )

• male mice exhibit gray hair in the inguinal region unlike wild-type mice

delayed hair regrowth ( J:159989 )

• dihydrotestosterone (DHT)-treated mice subjected to hair stripping exhibit delayed hair regrowth compared with similarly treated wild-type mice

• hair regrowth can be inhibited by dihydrotestosterone (DHT) treatment unlike in wild-type mice

• however, treatment with hydroxyflutamide (OHF) reverses this delay in regrowth

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
androgenic alopecia		DOID:0050801	OMIM:109200 OMIM:300710 OMIM:612421	J:159989