Phenotypes Associated with This Genotype

Genotype
MGI:4818990

• Allelic Composition: Tg(Prnp-APP*)1Hmor/0
• Genetic Background: B6.Cg-Tg(Prnp-APP*)1Hmor

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:159623 )

N • no amyloid plaques are observed unlike in Tg(APPSWE)2576Kha mice

microgliosis ( J:159623 )

• at 12 months

astrocytosis ( J:159623 )

• at 18 months

abnormal neuron morphology ( J:159623 )

• mice exhibit an intraneuronal accumulation of APP oligomers in the cerebral cortex, hippocampus, and cerebellum unlike in Tg(APPSWE)2576Kha or Tg(Prnp-APP)#Hmor mice

decreased neuron number ( J:159623 )

• at 24 months, fewer neurons are found in the hippocampal CA3 region compared to in wild-type mice

reduced long-term potentiation ( J:123688 )

decreased paired-pulse facilitation ( J:123688 )

behavior/neurological

abnormal spatial learning ( J:159623 )

• mice exhibit increased escape latency in a Morris water maze compared with Tg(Prnp-APP)#Hmor and wild-type mice

immune system

microgliosis ( J:159623 )

• at 12 months

hematopoietic system

microgliosis ( J:159623 )

• at 12 months

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:159623