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Phenotypes Associated with This Genotype
Genotype
MGI:4819006
Allelic
Composition
Ightm1(Myc)Janz/Igh+
Tg(Emu-FGFR3)A5Wmk/0
Genetic
Background
involves: 129X1/SvJ * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ightm1(Myc)Janz mutation (2 available); any Igh mutation (44 available)
Tg(Emu-FGFR3)A5Wmk mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• tumors are less differentiated than tumors from Ightm1(Myc)Janz heterozygotes
• 98% of mice developed tumors at a median age of 156 days unlike wild-type mice
• 1 tumor exhibits plasmacytoid differentiation

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
multiple myeloma DOID:9538 OMIM:254500
J:160845


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory