Phenotypes Associated with This Genotype

Genotype
MGI:4819098

• Allelic Composition: Nog^tm1Amc/Nog^tm1Amc; Smad3^tm1Xfw/Smad3⁺
• Genetic Background: involves: 129/Sv * 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

holoprosencephaly ( J:161524 )

• in 29% of mice

embryo

abnormal mesendoderm development ( J:161524 )

• expression analysis indicates defects in patterning and function in the anterior most axial mesendoderm

abnormal embryonic tissue morphology ( J:161524 )

• 29% (17 of 58) show defects in anterior midline tissues

abnormal anterior definitive endoderm morphology ( J:161524 )

• expression analysis indicates impairment in ADE specification

abnormal prechordal plate morphology ( J:161524 )

• expression analysis indicates defects in patterning and function

abnormal primitive streak formation ( J:161524 )

• expression analysis indicates a defect in anterior primitive streak development

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
holoprosencephaly		DOID:4621	OMIM:PS236100	J:161524