Phenotypes Associated with This Genotype

Genotype
MGI:4819110

• Allelic Composition: Tg(Thy1-APPDutch)#Jckr/0
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

microgliosis ( J:92796 )

immune system

microgliosis ( J:92796 )

nervous system

microgliosis ( J:92796 )

amyloid beta deposits ( J:92796 , J:162531 )

• vascular amyloid deposition at approximately 22-25 months with female mice having an earlier onset than males (J:92796)

cerebral amyloid angiopathy ( J:162531 )

• cerebrovascular amyloid restricted to leptomeningeal and cortical vessels

astrocytosis ( J:92796 )

brain ischemia ( J:92796 )

cardiovascular system

vascular smooth muscle hypoplasia ( J:92796 )

• amyloid-laden vessels show a severe loss of smooth muscle cells

hemorrhage ( J:92796 )

• fresh hemorrhages, as well as indications of previous hemorrhages are found

muscle

vascular smooth muscle hypoplasia ( J:92796 )

• amyloid-laden vessels show a severe loss of smooth muscle cells

cellular

abnormal basement membrane morphology ( J:92796 )

• an irregular thickening of the basement membrane with amorphous material in some vessels

• amyloid fibrils within the basement membrane, predominantly on the adventitial side

homeostasis/metabolism

amyloidosis ( J:92796 )

amyloid beta deposits ( J:92796 , J:162531 )

• vascular amyloid deposition at approximately 22-25 months with female mice having an earlier onset than males (J:92796)

cerebral amyloid angiopathy ( J:162531 )

• cerebrovascular amyloid restricted to leptomeningeal and cortical vessels

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cerebral amyloid angiopathy		DOID:9246		J:92796 , J:162531