Phenotypes Associated with This Genotype

Genotype
MGI:4819172

• Allelic Composition: Tg(Lck-LMO1)11Sjk/0; Tg(STIL-TAL1)A5(3)Alpa/0
• Genetic Background: involves: C3H * C3H/HeRos * C57BL/6 * C57BL/10Ros

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

enlarged thymus ( J:40868 )

increased T cell derived lymphoma incidence ( J:40868 )

• 95% of mice develop aggressive T cell leukemia/lymphomas within 6 months

enlarged spleen ( J:40868 )

decreased bone marrow cell number ( J:40868 )

• lymphoblasts replace bone marrow

decreased erythrocyte cell number ( J:40868 )

thrombocytopenia ( J:40868 )

increased leukocyte cell number ( J:40868 )

• in some mice

neoplasm

increased T cell derived lymphoma incidence ( J:40868 )

• 95% of mice develop aggressive T cell leukemia/lymphomas within 6 months

increased leukemia incidence ( J:40868 )

• 95% of mice develop aggressive T cell leukemia/lymphomas within 6 months

behavior/neurological

lethargy ( J:40868 )

liver/biliary system

enlarged liver ( J:40868 )

respiratory system

respiratory distress ( J:40868 )

immune system

enlarged thymus ( J:40868 )

increased T cell derived lymphoma incidence ( J:40868 )

• 95% of mice develop aggressive T cell leukemia/lymphomas within 6 months

enlarged spleen ( J:40868 )

increased leukocyte cell number ( J:40868 )

• in some mice

enlarged lymph nodes ( J:40868 )

• peripheral

abnormal inflammatory response ( J:40868 )

• mice exhibit widespread organ infiltration including liver, kidney, lung, and bone marrow

endocrine/exocrine glands

enlarged thymus ( J:40868 )

increased T cell derived lymphoma incidence ( J:40868 )

• 95% of mice develop aggressive T cell leukemia/lymphomas within 6 months

growth/size/body

enlarged liver ( J:40868 )

enlarged spleen ( J:40868 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
acute lymphoblastic leukemia		DOID:9952	OMIM:247640 OMIM:613065	J:40868