Phenotypes Associated with This Genotype

Genotype
MGI:4819227

• Allelic Composition: Id4^tm1Fsky/Id4^tm1Fsky
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:162236 )

• mice die by 5 weeks

skeleton

skeleton phenotype ( J:162236 )

N • mice did not exhibit skeletal deformities

abnormal bone structure ( J:162236 )

• the sixth lumbar vertebrae exhibits decreased bone volume compared with wild-type mice

• osteoid thickness in the lateral calvarial bone is reduced compared to in wild-type mice

abnormal osteoblast morphology ( J:162236 )

• the number of two II osteoblast is decreased while the number of type IV osteoblasts is increased compared to in wild-type mice

• however, the total number of ostoblasts is normal

abnormal epiphyseal plate morphology ( J:162236 )

• the growth plate width and longitudinal growth rate is decreased compared to in wild-type mice

decreased bone mineralization ( J:162236 )

• mineral apposition rate of the calvaria bone is reduced compared to in wild-type mice

decreased bone ossification ( J:162236 )

• lumbar and calvaria bones exhibit reduced bone formation to bone surface ratio compared with wild-type mice

adipose tissue

abnormal fat cell morphology ( J:162236 )

• the number of adipocytes in the epiphyseal tibia bone marrow is increased compared to in wild-type mice

• the number of adipocytes in the lateral calvaria bone is increased compared to in wild-type mice

growth/size/body

decreased body weight ( J:162236 )

decreased body length ( J:162236 )

postnatal growth retardation ( J:162236 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
osteoporosis		DOID:11476	OMIM:166710	J:162236