Phenotypes for Tg(TRP53*R72P)7Dgj Trp53 MGI:4819640 MGI Mouse

About Help FAQ

Phenotypes Associated with This Genotype

Allelic Composition	Tg(TRP53*R72P)7Dgj/0 Trp53^tm1Tyj/Trp53^tm1Tyj
Genetic Background	involves: 129S2/SvPas * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(TRP53*R72P)7Dgj mutation (0 available)
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (244 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased lymphoma incidence ( J:162466 )

• development of early lymphomas in Trp53^tm1Tyj homozygotes is rescued

increased hemangiosarcoma incidence ( J:162466 )

• more common than in Tg(TRP53)4Dgj mice

cellular

decreased cellular sensitivity to ultraviolet irradiation ( J:162466 )

• UV-exposed mice exhibit increased apoptosis in the skin compared with similarly treated Tg(TRP53)4Dgj mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24