Phenotypes Associated with This Genotype

Genotype
MGI:4819722

• Allelic Composition: Tg(Myh6-TNNT2*R92Q)#Ajm/0
• Genetic Background: involves: C3H * C57BL/6 * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:161899 )

N • no change in survival is detected in mice up to 2 years of age

cardiovascular system

cardiovascular system phenotype ( J:161899 )

N • no increase in heart weight is detected

abnormal myocardial fiber morphology ( J:161899 , J:162685 )

• cardiomyocyte disarray (J:161899)

• cardiomyocyte disarray comprising about 27% of the myocardium compared to about 4% in controls (J:162685)

abnormal heart left ventricle morphology ( J:161899 )

• decrease in left ventricular end systolic diameters

cardiac interstitial fibrosis ( J:161899 , J:162685 )

• increase in the collagen volume fraction (J:161899)

• in 2/3 of 3 to 12 month old mice (J:162685)

• treatment with Losartan significantly reduces interstitial fibrillar collagen (J:162685)

abnormal cardiovascular system physiology ( J:161899 )

• increase in left ventricular systolic function

muscle

abnormal myocardial fiber morphology ( J:161899 , J:162685 )

• cardiomyocyte disarray (J:161899)

• cardiomyocyte disarray comprising about 27% of the myocardium compared to about 4% in controls (J:162685)

cellular

cardiac interstitial fibrosis ( J:161899 , J:162685 )

• increase in the collagen volume fraction (J:161899)

• in 2/3 of 3 to 12 month old mice (J:162685)

• treatment with Losartan significantly reduces interstitial fibrillar collagen (J:162685)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hypertrophic cardiomyopathy 2		DOID:0110308	OMIM:115195	J:161899 , J:162685