Phenotypes Associated with This Genotype

Genotype
MGI:4819724

• Allelic Composition: Tg(Myh6-TNNT2*R141W)#Ajm/0
• Genetic Background: involves: C3H * C57BL/6 * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:161899 )

• 29% of mice die within 1 year and almost all die by 2 years of age

cardiovascular system

enlarged heart ( J:161899 )

increased heart weight ( J:161899 )

• increase in the ventricular weight to body weight ratio compared to age and sex matched controls

cardiac hypertrophy ( J:161899 )

• increase in expression of markers of cardiac hypertrophy

abnormal heart left ventricle morphology ( J:161899 )

• increase in left ventricular end systolic and end diastolic diameters

increased heart left ventricle weight ( J:161899 )

cardiac interstitial fibrosis ( J:161899 )

• increase in the collagen volume fraction

abnormal cardiovascular system physiology ( J:161899 )

• decrease in left ventricular systolic function

growth/size/body

enlarged heart ( J:161899 )

increased heart weight ( J:161899 )

• increase in the ventricular weight to body weight ratio compared to age and sex matched controls

cardiac hypertrophy ( J:161899 )

• increase in expression of markers of cardiac hypertrophy

cellular

cardiac interstitial fibrosis ( J:161899 )

• increase in the collagen volume fraction

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
dilated cardiomyopathy 1D		DOID:0110426	OMIM:601494	J:161899