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Phenotypes Associated with This Genotype
Genotype
MGI:4820732
hm1
Allelic
Composition		 Btkvila/Btkvila
Genetic
Background		 C57BL/6JAnu-Btkvila/AnuApb
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Btkvila mutation (2 available); any Btk mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal leukocyte morphology ( J:104190 )
• flow cytometric analysis reveals decreased cell surface expression of CD45 (leukocyte common antigen)
decreased B cell number ( J:104190 )
• detected in peripheral blood by flow cytometry
decreased IgD level ( J:104190 )
• flow cytometric analysis reveals decreased B cell surface IgD expression
increased IgE level ( J:104190 )
• flow cytometric analysis reveals dramatically elevated IgE expression on B cells ("hyper IgE")
increased IgG level ( J:104190 )
• flow cytometric analysis reveals increased IgG expression on B cells

immune system
abnormal leukocyte morphology ( J:104190 )
• flow cytometric analysis reveals decreased cell surface expression of CD45 (leukocyte common antigen)
decreased B cell number ( J:104190 )
• detected in peripheral blood by flow cytometry
decreased IgD level ( J:104190 )
• flow cytometric analysis reveals decreased B cell surface IgD expression
increased IgE level ( J:104190 )
• flow cytometric analysis reveals dramatically elevated IgE expression on B cells ("hyper IgE")
increased IgG level ( J:104190 )
• flow cytometric analysis reveals increased IgG expression on B cells

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory