Phenotypes Associated with This Genotype

Genotype
MGI:4820817

cn1

• Allelic Composition: Itga5^tm2Hyn/Itga5^tm2Hyn
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal neuronal migration ( J:159465 )

• impaired radial migration with an accumulation of migrating neurons in the ventral region of the cortex as opposed to wild-type cortical neurons which migrate normally away from the ventricular/sub-ventricular zone to reach the cortical plate when electroporated with Cre recombinase in cortical progenitor cells in the ventricular region of cerebral cortex

abnormal cerebral cortex morphology ( J:159465 )

• in some regions along the cerebral cortex neurons form clusters and show morphological abnormalities with formation of multiple neuronal protrusions when electroporated with Cre recombinase in cortical progenitor cells in the ventricular region of cerebral cortex

cellular

abnormal neuronal migration ( J:159465 )

• impaired radial migration with an accumulation of migrating neurons in the ventral region of the cortex as opposed to wild-type cortical neurons which migrate normally away from the ventricular/sub-ventricular zone to reach the cortical plate when electroporated with Cre recombinase in cortical progenitor cells in the ventricular region of cerebral cortex