hematopoietic system
• exhibit an increased number of atypical lymphoid cells and numerous malignant lymphoid cells
|
• expanded CD5+ B-cell population in spleen, peripheral blood and bone marrow
|
• distorted architecture with lymphoid follicles in disarray
|
• mice show impaired immune response in production of anti-sheep RBC (SRBC) antibodies after injection of SRBC
|
• increased B220+, Ki67+ immunohistochemical staining
|
immune system
• exhibit an increased number of atypical lymphoid cells and numerous malignant lymphoid cells
|
• expanded CD5+ B-cell population in spleen, peripheral blood and bone marrow
|
• distorted architecture with lymphoid follicles in disarray
|
• mice show impaired immune response in production of anti-sheep RBC (SRBC) antibodies after injection of SRBC
|
• increased B220+, Ki67+ immunohistochemical staining
|
neoplasm
• 50% CD5+CD19+IgM+ B cells shows clonal rearrangements of the IgH gene in three of five cases analyzed
|
growth/size/body
• distorted architecture with lymphoid follicles in disarray
|
cellular
• increased B220+, Ki67+ immunohistochemical staining
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
chronic lymphocytic leukemia | DOID:1040 |
OMIM:109543 OMIM:151400 OMIM:609630 OMIM:612557 OMIM:612558 OMIM:612559 |
J:162077 |