Phenotypes Associated with This Genotype

Genotype
MGI:4820822

• Allelic Composition: Tg(Igh-Mir29a,-Mir29b-1,-hrGFP)#Cro/0; Tg(Igh-V186.2-TCL1A)3Cro/0
• Genetic Background: involves: C3H * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

spleen hyperplasia ( J:162077 )

• 3-fold increases in spleen weight compared to Tg(Igh-V186.2-TCL1A)3Cro mice alone

increased B-1a cell number ( J:162077 )

• increased number of CD5+ B cells in spleen

immune system

spleen hyperplasia ( J:162077 )

• 3-fold increases in spleen weight compared to Tg(Igh-V186.2-TCL1A)3Cro mice alone

increased B-1a cell number ( J:162077 )

• increased number of CD5+ B cells in spleen

neoplasm

increased chronic lymphocytic leukemia incidence ( J:162077 )

• a significant increased number of CD5+CD19+ and CD5+IgM+ B-cell populations compared with Tg(Igh-V186.2-TCL1A)3Cro mice alone

growth/size/body

spleen hyperplasia ( J:162077 )

• 3-fold increases in spleen weight compared to Tg(Igh-V186.2-TCL1A)3Cro mice alone

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
chronic lymphocytic leukemia		DOID:1040	OMIM:109543 OMIM:151400 OMIM:609630 OMIM:612557 OMIM:612558 OMIM:612559	J:162077