Phenotypes Associated with This Genotype

Genotype
MGI:4820839

• Allelic Composition: Gck^m1Rge/Gck⁺
• Genetic Background: involves: C3HeB/FeJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased insulin secretion ( J:162903 )

• marginally in beta cells of male mice

hyperglycemia ( J:162903 )

• slightly in fed mice from the first days of life

• significantly at 30 days of age

• at 30 days during a glucose tolerance test

increased circulating insulin level ( J:162903 )

• in fasted male mice and after oral glucose administration at 90 and 180 days

impaired glucose tolerance ( J:162903 )

insulin resistance ( J:162903 )

• slightly in male mice

endocrine/exocrine glands

decreased pancreatic beta cell mass ( J:162903 )

• in male, but not female, mice

small pancreatic islets ( J:162903 )

• in male, but not female, mice

decreased insulin secretion ( J:162903 )

• marginally in beta cells of male mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
maturity-onset diabetes of the young type 2		DOID:0111100	OMIM:125851	J:162903