Phenotypes Associated with This Genotype

Genotype
MGI:4821001

• Allelic Composition: Tacr1^tm1Sph/Tacr1^tm1Sph
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired behavioral response to addictive substance ( J:171881 )

• amphetamine- or morphine-treated mice lack conditioned place preference unlike wild-type mice

impaired behavioral response to morphine ( J:171881 )

• morphine-treated mice lack conditioned place preference unlike wild-type mice

impaired conditioned place preference behavior ( J:171881 )

• amphetamine- or morphine-treated mice lack conditioned place preference unlike wild-type mice

impaired coordination ( J:171881 )

• on a rotarod

hyperactivity ( J:171881 )

• mice exhibit hyperactivity compared with wild-type mice

• however, hyperactivity is rescued by D-amphetamine or methylphenidate treatment

abnormal pain threshold ( J:127006 )

• F2rl1(PAR2)-agonist-induced hyperalgesia is not observed in mutants as is seen in wild-type mice

homeostasis/metabolism

abnormal dopamine level ( J:171881 )

• mice exhibit reduced basal dopamine efflux in the frontal cortex compared with wild-type mice

• amphetamine-treated mice lack a dopamine response compared with wild-type mice

abnormal noradrenaline level ( J:171881 )

• after a second potassium ion challenge, extracellular noradrenaline level is increased unlike in wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
attention deficit hyperactivity disorder		DOID:1094	OMIM:143465 OMIM:608903 OMIM:608904 OMIM:608905 OMIM:608906 OMIM:612311 OMIM:612312	J:171881