Phenotypes Associated with This Genotype

Genotype
MGI:4822144

• Allelic Composition: avc3/avc3
• Genetic Background: involves: C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality ( J:163196 )

embryonic lethality, incomplete penetrance ( J:163196 )

• at E14, 30% of mutants exhibit embryonic lethality

cardiovascular system

abnormal myocardium compact layer morphology ( J:163196 )

• mutant mice exhibit diminished compact myocardium

complete atrioventricular septal defect ( J:163196 )

• mutant mice develop atrioventricular septal defects of the complete common atrioventricular canal type

muscle

abnormal myocardium compact layer morphology ( J:163196 )

• mutant mice exhibit diminished compact myocardium

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
atrioventricular septal defect		DOID:0050651	OMIM:606215 OMIM:614430 OMIM:614474	J:163196