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Phenotypes Associated with This Genotype
Genotype
MGI:4822435
cx5
Allelic
Composition		 Tcrbtm1Mom/Tcrb+
Tg(SOD1*G93A)1Gur/0
Genetic
Background		 B6.Cg-Tcrbtm1Mom Tg(SOD1*G93A)1Gur/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcrbtm1Mom mutation (12 available); any Tcrb mutation (97 available)
Tg(SOD1*G93A)1Gur mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:143173 )
• accelerated disease progression
• shorter lifespans than Tg(SOD1*G93A)1Gur and Tg(SOD1*G93A)1Gur, Tcrbtm1Mom heterozygous mice

growth/size/body
weight loss ( J:143173 )
• accelerated weight loss after disease onset compared to Tg(SOD1*G93A)1Gur, Tcrbtm1Mom heterozygous littermates, mainly after day 135

nervous system
abnormal microglial cell physiology ( J:143173 )
• decreased microglia reactivity
motor neuron degeneration ( J:143173 )
• accelerated disease progression
• motor neuron loss in spinal cords earlier at day 140
• accelerated motor decline after disease onset compared to Tg(SOD1*G93A)1Gur, Tcrbtm1Mom heterozygous littermates, mainly after day 135

immune system
abnormal microglial cell physiology ( J:143173 )
• decreased microglia reactivity

hematopoietic system
abnormal microglial cell physiology ( J:143173 )
• decreased microglia reactivity

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory