Analysis Tools
behavior/neurological
| N |
• mice exhibit normal gait pattern and limb strength between 16 and 84 weeks of age
|
|
• beginning at 16 weeks on a rotarod
• homozygous mice tend to spend less time on a rotarod than heterozygous mice
|
|
• mice exhibit a decrease of locomotor activity compared with wild-type mice
|
nervous system
astrocytosis
(
J:163032
)
|
• at 49 weeks in the substantia nigra and vestibular nuclei
|
|
• at 16 weeks, mice exhibit mild neuronal atrophy in areas such as the pontine and dentate nuclei unlike wild-type mice
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Machado-Joseph disease | DOID:1440 |
OMIM:109150 |
J:163032 | |
