Phenotypes Associated with This Genotype

Genotype
MGI:4829793

• Allelic Composition: Pten^tm1Hwu/Pten^tm1Hwu; Tg(MMTV-cre)4Mam/0
• Genetic Background: involves: 129S4/SvJae * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal branching of the mammary ductal tree ( J:78415 )

♀ • transplanted mammary epithelium exhibits more and feather-like irregular side-branches in ductal and terminal structures compared with controls

mammary gland duct hyperplasia ( J:78415 )

♀ • transplants from virgins exhibit focal ductal hyperplasia containing papillary structure

♀ • after one pregnancy, transplants exhibit intra-luminal focal hyperplasia

integument

abnormal branching of the mammary ductal tree ( J:78415 )

♀ • transplanted mammary epithelium exhibits more and feather-like irregular side-branches in ductal and terminal structures compared with controls

mammary gland duct hyperplasia ( J:78415 )

♀ • transplants from virgins exhibit focal ductal hyperplasia containing papillary structure

♀ • after one pregnancy, transplants exhibit intra-luminal focal hyperplasia

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Cowden syndrome		DOID:6457	OMIM:PS158350	J:78415