Phenotypes Associated with This Genotype

Genotype
MGI:4830462

• Allelic Composition: Htr2c^tm1.1Eme/Y
• Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality at weaning, incomplete penetrance ( J:163043 )

♂ • Background Sensitivity: on a predominantly 129S6/SvEvTac background,10% to 20% of mice die between P21 and P24

postnatal lethality, incomplete penetrance ( J:163043 )

♂ • Background Sensitivity: in a cross with a C57BL/6J male, 75% of mice die between P8 and P12 with none surviving beyond P15

♂ • however, mortality can be minimized by feeding wet food paste on a predominantly 129S6/SvEvTac background

behavior/neurological

decreased food intake ( J:163043 )

♂ • gastric milk content is decreased compared to in wild-type mice

increased food intake ( J:163043 )

♂ • in adult mice when food consumption is corrected for weight

abnormal pilomotor reflex ( J:163043 )

♂

impaired coordination ( J:163043 )

♂ • in weanlings (P2-P28) but not adults on a rotarod

decreased grip strength ( J:163043 )

♂ • in weanlings (P2-P28) but not adults

hunched posture ( J:163043 )

♂

growth/size/body

decreased body weight ( J:163043 )

♂ • at P21 despite normal birth weight

decreased body length ( J:163043 )

♂

postnatal growth retardation ( J:163043 )

♂ • mice fail to thrive after birth

♂ • however, mice exhibit normal growth rate after weaning

homeostasis/metabolism

increased energy expenditure ( J:163043 )

♂ • total and resting energy adjusted for body weight are increased compared to in wild-type mice

dehydration ( J:163043 )

♂

muscle

hypotonia ( J:163043 )

♂

pigmentation

mottled coat ( J:163043 )

♂

integument

mottled coat ( J:163043 )

♂

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Prader-Willi syndrome		DOID:11983	OMIM:176270	J:163043