Phenotypes Associated with This Genotype

Genotype
MGI:4830468

• Allelic Composition: Ank2^tm1Bnt/Ank2⁺
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased heart rate variability ( J:163867 )

• in isoproterenol-treated mice

abnormal sinoatrial node conduction ( J:163867 )

• isoproterenol-treated mice exhibit disorganized shifts of the leading pacemaker and competing multiple pacemakers compared with similarly treated wild-type mice

• acetylcholine-treated mice exhibit reduced sensitivity of pacemaker function compared with similarly treated wild-type mice

homeostasis/metabolism

abnormal physiological response to xenobiotic ( J:163867 )

• isoproterenol-treated mice exhibit increased heart rate variability, a larger beat-to-beat variability, disorganized shifts of the leading pacemaker, and competing multiple pacemakers compared with similarly treated wild-type mice

• acetylcholine-treated mice exhibit reduced sensitivity of pacemaker function compared with similarly treated wild-type mice

adipose tissue

abnormal fat cell differentiation ( J:222913 )

• mouse embryonic fibroblasts exhibit increased adipogenesis with both increased in adipocyte numbers and enlarged lipid droplets compared with wild-type cells.

decreased adipocyte glucose uptake ( J:222913 )

• decreased basal adipocyte glucose uptake

• however, insulin-stimulated uptake is normal

cellular

abnormal fat cell differentiation ( J:222913 )

• mouse embryonic fibroblasts exhibit increased adipogenesis with both increased in adipocyte numbers and enlarged lipid droplets compared with wild-type cells.

decreased adipocyte glucose uptake ( J:222913 )

• decreased basal adipocyte glucose uptake

• however, insulin-stimulated uptake is normal

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
sinoatrial node disease		DOID:0050824		J:163867