Phenotypes Associated with This Genotype

Genotype
MGI:4830779

hm1

• Allelic Composition: Comt^tm1Kara/Comt^tm1Kara
• Genetic Background: B6.129S4-Comt^tm1Kara

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased dopamine level ( J:164057 )

• elevated levels of dopamine in both the striatum and the medial prefrontal cortex in females compared with the values in the corresponding wild-type mice after oral administration of L-DOPA

abnormal xenobiotic pharmacokinetics ( J:164057 )

• an increase in plasma and liver L-DOPA in both sexes and intestinal L-DOPA levels in males after oral administration of L-DOPA, compared to wild-type