Phenotypes for Apoe Ccr2 Cx3cl1 MGI:4833678 MGI Mouse

About Help FAQ

Phenotypes Associated with This Genotype

Allelic Composition	Apoe^tm1Unc/Apoe^tm1Unc Ccr2^tm1Ifc/Ccr2^tm1Ifc Cx3cl1^tm1Lira/Cx3cl1^tm1Lira
Genetic Background	B6.Cg-Apoe^tm1Unc Cx3cl1^tm1Lira Ccr2^tm1Ifc

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoe^tm1Unc mutation (33 available); any Apoe mutation (158 available)
Ccr2^tm1Ifc mutation (1 available); any Ccr2 mutation (43 available)
Cx3cl1^tm1Lira mutation (0 available); any Cx3cl1 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

decreased susceptibility to atherosclerosis ( J:153310 )

• mice fed a high fat diet exhibit decreased lesion size and macrophage accumulation compared to in Apoe^tm1Unc homozygotes and Apoe^tm1Unc Ccr2^tm1Ifc homozygotes

hematopoietic system

decreased monocyte cell number ( J:153310 )

• mice fed a high fat diet exhibit decreased circulating monocyte numbers compared to in Apoe^tm1Unc homozygotes

• however, levels are the same as in Apoe^tm1Unc Ccr2^tm1Ifc homozygotes

immune system

decreased monocyte cell number ( J:153310 )

• mice fed a high fat diet exhibit decreased circulating monocyte numbers compared to in Apoe^tm1Unc homozygotes

• however, levels are the same as in Apoe^tm1Unc Ccr2^tm1Ifc homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/18/2025 MGI 6.24