Phenotypes Associated with This Genotype

Genotype
MGI:4833684

• Allelic Composition: Serpina6^tm1.1Mmp/Serpina6^tm1.1Mmp
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:164345 )

N • mice exhibit normal behavior in an elevated plus maze and open field

impaired behavioral response to cocaine ( J:164345 )

• cocaine-treated mice fail to exhibit a locomotor response sensitization unlike similarly treated wild-type mice

behavioral despair ( J:164345 )

• during sessions of inescapable footshock, mice exhibit increased learned helplessness escape failures and increased learned helplessness avoidance compared with similarly treated wild-type mice

• in a forced-swim test, mice exhibit increased level of immobility compared with similarly treated wild-type mice

homeostasis/metabolism

abnormal circulating corticosterone level ( J:164345 )

• morning, but not evening, concentrations of free corticosterone is greater than in wild-type mice

• stressed mice exhibit decreased free plasma corticosterone compared with similarly treated wild-type mice

• however, total corticosterone levels are normal

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
corticosteroid-binding globulin deficiency		DOID:0090030	OMIM:611489	J:164345 , J:192931