Phenotypes Associated with This Genotype

Genotype
MGI:4833954

cx5

• Allelic Composition: Abca1^tm1Jdm/Abca1^tm1Jdm; Tg(Thy1-APP)3Somm/0
• Genetic Background: involves: C57BL/6J * DBA/1LacJ * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:105902 )

• fewer than expected mice are present at weaning

nervous system

intracerebral hemorrhage ( J:105902 )

• mice exhibit more cerebral amyloid angiopathy-associated cerebral hemorrhage than Tg(Thy1-APP)3Somm mice

cerebral amyloid angiopathy ( J:105902 )

• at 13 months, mice exhibit more cerebral amyloid angiopathy than in Tg(Thy1-APP)3Somm mice

cardiovascular system

intracerebral hemorrhage ( J:105902 )

• mice exhibit more cerebral amyloid angiopathy-associated cerebral hemorrhage than Tg(Thy1-APP)3Somm mice

homeostasis/metabolism

amyloidosis ( J:105902 )

• mice exhibit a 2-fold increase in insoluble beta-amyloid in the brain compared with Tg(Thy1-APP)3Somm mice

cerebral amyloid angiopathy ( J:105902 )

• at 13 months, mice exhibit more cerebral amyloid angiopathy than in Tg(Thy1-APP)3Somm mice