Phenotypes Associated with This Genotype

Genotype
MGI:4834300

cx23

• Allelic Composition: Tg(Gria2*586N)238.2Rsp/0; Tg(SOD1*G93A)1Gur/0
• Genetic Background: involves: C57BL/6Ico

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:97818 )

• accelerated disease progression

• decreased survival (1932.93 vs. 208.45.06 days), compared with Tg(SOD1*G93A)1Gur mice

growth/size/body

weight loss ( J:97818 )

• declined body weight (14.3% over 51 days) after 20 weeks of age

behavior/neurological

impaired righting response ( J:97818 )

• lose righting reflex between 12 and 18 weeks

tremors ( J:97818 )

• accelerated onset (87.205.5 vs. 1856.3 days), compared with Tg(SOD1*G93A)1Gur mice

• in all 13 mice