Phenotypes Associated with This Genotype

Genotype
MGI:4834526

• Allelic Composition: Aspm^{Gt(AA0137)Wtsi}/Aspm^{Gt(AA0137)Wtsi}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6JOlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

decreased ovary weight ( J:164424 )

♀ • ovary weight is significantly reduced

decreased testis weight ( J:164424 )

♂ • Testis weight in newborn (P0.5), juvenile (P21), and adult (10 wk) is drastically reduced

nervous system

decreased brain size ( J:164424 )

• adult brains have a significant reduction in whole section area

decreased brain weight ( J:164424 )

• brains of newborn and adult mice are significantly reduced in weight

abnormal neocortex morphology ( J:164424 )

• adult brains have a reduced neocortex area

reproductive system

oligozoospermia ( J:164424 )

♂

small sperm head ( J:164424 )

♂ • significant reduction in head area

asthenozoospermia ( J:164424 )

♂ • reduced track speed of motile sperm

decreased ovary weight ( J:164424 )

♀ • ovary weight is significantly reduced

decreased testis weight ( J:164424 )

♂ • Testis weight in newborn (P0.5), juvenile (P21), and adult (10 wk) is drastically reduced

reduced female fertility ( J:164424 )

♀ • when females mated with wild-type males they have significantly fewer embryos

reduced male fertility ( J:164424 )

♂ • when males are mated with wild-type females they exhibit a much lower pregnancy rate

growth/size/body

decreased body weight ( J:164424 )

• body weight is reduced in newborns

microcephaly ( J:164424 )

cellular

oligozoospermia ( J:164424 )

♂

small sperm head ( J:164424 )

♂ • significant reduction in head area

asthenozoospermia ( J:164424 )

♂ • reduced track speed of motile sperm

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
microcephaly		DOID:10907		J:164424