Phenotypes Associated with This Genotype

Genotype
MGI:4834606

cx4

• Allelic Composition: Gria2^tm1Rod/Gria2^tm1Rod; Tg(SOD1*G93A)1Gur/0
• Genetic Background: B6.Cg-Gria2^tm1Rod Tg(SOD1*G93A)1Gur

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:104951 )

• shortened lifespan (116.50.6 vs. 137.12.6 days), compare with Tg(SOD1*G93A)1Gur mice

behavior/neurological

impaired coordination ( J:104951 )

• unable to walk on a rotarod

decreased grip strength ( J:104951 )

• decreased grip strength in forelimbs

hindlimb paralysis ( J:104951 )

• earlier onset (99.32.1 days vs. 117.31.8 days), compare with Tg(SOD1*G93A)1Gur mice

nervous system

decreased motor neuron number ( J:104951 )

• decreased number of the large neurons in the ventral horn of the lumbar spinal cord

abnormal AMPA-mediated synaptic currents ( J:104951 )

• higher elevations of the intracellular Ca2+ concentration upon AMPA receptor stimulation