Phenotypes for Adamts13 Vwf MGI:4834624 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Adamts13^tm1Dgi/Adamts13^tm1Dgi Vwf^tm1Wgr/Vwf^tm1Wgr
Genetic Background	involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * CASA/Rk

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts13^tm1Dgi mutation (1 available); any Adamts13 mutation (70 available)
Vwf^tm1Wgr mutation (1 available); any Vwf mutation (140 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased susceptibility to xenobiotic induced morbidity/mortality ( J:133469 )

• in shigatoxin (Stx)-treated mice

homeostasis/metabolism

decreased susceptibility to xenobiotic induced morbidity/mortality ( J:133469 )

• in shigatoxin (Stx)-treated mice

decreased physiological sensitivity to xenobiotic ( J:133469 )

• shigatoxin (Stx)-treated mice exhibit less severe thrombocytopenia and reduced mortality compared with similarly treated Adamts13^tm1Dgi homozygotes

hematopoietic system

abnormal platelet morphology ( J:133469 )

• shigatoxin (Stx)-treated mice exhibit less severe thrombocytopenia and reduced mortality compared with similarly treated Adamts13^tm1Dgi homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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