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Phenotypes Associated with This Genotype
Genotype
MGI:4834760
cx14
Allelic
Composition		 Il6tm1Kopf/Il6tm1Kopf
Liftm1Stw/Liftm1Stw
Genetic
Background		 involves: 129S1/Sv * 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il6tm1Kopf mutation (9 available); any Il6 mutation (38 available)
Liftm1Stw mutation (1 available); any Lif mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased susceptibility to injury ( J:89814 )
• 24 hours after scalpel cortex injury, mice exhibit reduced microglial and astrocyte reaction compared with similarly treated wild-type mice but similar to in single homozygotes

nervous system
abnormal glial cell morphology ( J:89814 )
• 24 hours after scalpel cortex injury, mice exhibit reduced microglial and astrocyte reaction compared with similarly treated wild-type mice but similar to in single homozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory