Phenotypes Associated with This Genotype

Genotype
MGI:4834994

hm2

• Allelic Composition: Fosl2^tm2.1Wag/Fosl2^tm2.1Wag
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal osteoclast morphology ( J:137646 )

• oteoclast number and size are increased compared to in wild-type mice

abnormal osteoclast differentiation ( J:137646 )

• fetal liver derived osteoclast progenitors fail to differentiate in vitro unlike similarly treated wild-type cells

increased osteoclast cell number ( J:137646 )

abnormal osteoclast physiology ( J:137646 )

• osteoclast progenitors exhibit increased apoptosis compared with wild-type cells

• osteoclasts are hypoxic unlike in wild-type mice

decreased bone mineral density ( J:137646 )

• at birth

increased bone resorption ( J:137646 )

homeostasis/metabolism

hypoxia ( J:137646 )

• osteoclasts are hypoxic unlike in wild-type mice

immune system

abnormal osteoclast morphology ( J:137646 )

• oteoclast number and size are increased compared to in wild-type mice

abnormal osteoclast differentiation ( J:137646 )

• fetal liver derived osteoclast progenitors fail to differentiate in vitro unlike similarly treated wild-type cells

increased osteoclast cell number ( J:137646 )

abnormal osteoclast physiology ( J:137646 )

• osteoclast progenitors exhibit increased apoptosis compared with wild-type cells

• osteoclasts are hypoxic unlike in wild-type mice

hematopoietic system

abnormal osteoclast morphology ( J:137646 )

• oteoclast number and size are increased compared to in wild-type mice

abnormal osteoclast differentiation ( J:137646 )

• fetal liver derived osteoclast progenitors fail to differentiate in vitro unlike similarly treated wild-type cells

increased osteoclast cell number ( J:137646 )

abnormal osteoclast physiology ( J:137646 )

• osteoclast progenitors exhibit increased apoptosis compared with wild-type cells

• osteoclasts are hypoxic unlike in wild-type mice

cellular

abnormal osteoclast differentiation ( J:137646 )

• fetal liver derived osteoclast progenitors fail to differentiate in vitro unlike similarly treated wild-type cells