Phenotypes for Cdkn2a Tg(Tyr-HRAS)60Lc MGI:4835048 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp X/Tg(Tyr-HRAS)60Lc
Genetic Background	involves: 129/Sv * C57BL/6J * CBA/J * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2a^tm1Rdp mutation (6 available); any Cdkn2a mutation (66 available)
Tg(Tyr-HRAS)60Lc mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased tumor-free survival time ( J:164588 )

• mice are euthanized within 20 weeks due to tumor development

neoplasm

decreased tumor growth/size ( J:164588 )

• tumor growth is less aggressive than in Cdkn2a^tm2.1Nesh/Cdkn2a^tm2.1Nesh Kras^tm4Tyj/Kras⁺ Trp53^tm1Brn/Trp53^tm1Brn Tg(Tyr-cre/ERT2)13Bos mice

increased melanoma incidence ( J:164588 )

• all mice develop melanomas within 20 weeks

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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