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Phenotypes Associated with This Genotype
Genotype
MGI:4836243
Allelic
Composition
Ptentm1Ppp/Pten+
Tg(Pbsn-TAg)15Tvd/0
Genetic
Background
involves: 129S1/Sv * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Ppp mutation (0 available); any Pten mutation (88 available)
Tg(Pbsn-TAg)15Tvd mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• onset of lesions is accelerated compared to single transgenic Tg(Pbsn-TAg)15Tvd mice; by 8 weeks of age, mutant prostates show pronounced cribriform and tufting of epithelial cells that are not seen until 12 weeks of age in single transgenic Tg(Pbsn-TAg)15Tvd mice
• onset of adenocarcinoma is accelerated compared to single transgenic Tg(Pbsn-TAg)15Tvd mice, most likely due to a reduction in apoptosis
• some prostate abnormalities are different than in single transgenic Tg(Pbsn-TAg)15Tvd mice; pale cell carcinomas appear at around 17 weeks of age as do large focal adenocarcinomas with abundant cytoplasm and abnormal glandular growth patterns
• tumors show local microinvasion as well as invasion to distant sites in the urogenital system such as the seminal vesicle
• onset of mPIN is accelerated compared to single transgenic Tg(Pbsn-TAg)15Tvd mice, most likely due to a reduction in apoptosis
• mPIN lesions increase in severity with age
• epithelial proliferation in the prostate remains similar to single transgenic Tg(Pbsn-TAg)15Tvd mice
• apoptosis in the prostate is reduced compared to single transgenic Tg(Pbsn-TAg)15Tvd mice

reproductive system
• onset of lesions is accelerated compared to single transgenic Tg(Pbsn-TAg)15Tvd mice; by 8 weeks of age, mutant prostates show pronounced cribriform and tufting of epithelial cells that are not seen until 12 weeks of age in single transgenic Tg(Pbsn-TAg)15Tvd mice
• onset of adenocarcinoma is accelerated compared to single transgenic Tg(Pbsn-TAg)15Tvd mice, most likely due to a reduction in apoptosis
• some prostate abnormalities are different than in single transgenic Tg(Pbsn-TAg)15Tvd mice; pale cell carcinomas appear at around 17 weeks of age as do large focal adenocarcinomas with abundant cytoplasm and abnormal glandular growth patterns
• tumors show local microinvasion as well as invasion to distant sites in the urogenital system such as the seminal vesicle
• onset of mPIN is accelerated compared to single transgenic Tg(Pbsn-TAg)15Tvd mice, most likely due to a reduction in apoptosis
• mPIN lesions increase in severity with age
• epithelial proliferation in the prostate remains similar to single transgenic Tg(Pbsn-TAg)15Tvd mice
• apoptosis in the prostate is reduced compared to single transgenic Tg(Pbsn-TAg)15Tvd mice

neoplasm
• onset of lesions is accelerated compared to single transgenic Tg(Pbsn-TAg)15Tvd mice; by 8 weeks of age, mutant prostates show pronounced cribriform and tufting of epithelial cells that are not seen until 12 weeks of age in single transgenic Tg(Pbsn-TAg)15Tvd mice
• onset of adenocarcinoma is accelerated compared to single transgenic Tg(Pbsn-TAg)15Tvd mice, most likely due to a reduction in apoptosis
• some prostate abnormalities are different than in single transgenic Tg(Pbsn-TAg)15Tvd mice; pale cell carcinomas appear at around 17 weeks of age as do large focal adenocarcinomas with abundant cytoplasm and abnormal glandular growth patterns
• tumors show local microinvasion as well as invasion to distant sites in the urogenital system such as the seminal vesicle
• onset of mPIN is accelerated compared to single transgenic Tg(Pbsn-TAg)15Tvd mice, most likely due to a reduction in apoptosis
• mPIN lesions increase in severity with age


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory