Phenotypes Associated with This Genotype

Genotype
MGI:4836243

• Allelic Composition: Pten^tm1Ppp/Pten⁺; Tg(Pbsn-TAg)15Tvd/0
• Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

increased prostate gland tumor incidence ( J:103408 )

♂ • onset of lesions is accelerated compared to single transgenic Tg(Pbsn-TAg)15Tvd mice; by 8 weeks of age, mutant prostates show pronounced cribriform and tufting of epithelial cells that are not seen until 12 weeks of age in single transgenic Tg(Pbsn-TAg)15Tvd mice

increased prostate gland adenocarcinoma incidence ( J:103408 )

♂ • onset of adenocarcinoma is accelerated compared to single transgenic Tg(Pbsn-TAg)15Tvd mice, most likely due to a reduction in apoptosis

♂ • some prostate abnormalities are different than in single transgenic Tg(Pbsn-TAg)15Tvd mice; pale cell carcinomas appear at around 17 weeks of age as do large focal adenocarcinomas with abundant cytoplasm and abnormal glandular growth patterns

♂ • tumors show local microinvasion as well as invasion to distant sites in the urogenital system such as the seminal vesicle

increased prostate intraepithelial neoplasia incidence ( J:103408 )

♂ • onset of mPIN is accelerated compared to single transgenic Tg(Pbsn-TAg)15Tvd mice, most likely due to a reduction in apoptosis

♂ • mPIN lesions increase in severity with age

abnormal prostate gland physiology ( J:103408 )

♂ • epithelial proliferation in the prostate remains similar to single transgenic Tg(Pbsn-TAg)15Tvd mice

♂ • apoptosis in the prostate is reduced compared to single transgenic Tg(Pbsn-TAg)15Tvd mice

reproductive system

increased prostate gland tumor incidence ( J:103408 )

♂ • onset of lesions is accelerated compared to single transgenic Tg(Pbsn-TAg)15Tvd mice; by 8 weeks of age, mutant prostates show pronounced cribriform and tufting of epithelial cells that are not seen until 12 weeks of age in single transgenic Tg(Pbsn-TAg)15Tvd mice

increased prostate gland adenocarcinoma incidence ( J:103408 )

♂ • onset of adenocarcinoma is accelerated compared to single transgenic Tg(Pbsn-TAg)15Tvd mice, most likely due to a reduction in apoptosis

♂ • some prostate abnormalities are different than in single transgenic Tg(Pbsn-TAg)15Tvd mice; pale cell carcinomas appear at around 17 weeks of age as do large focal adenocarcinomas with abundant cytoplasm and abnormal glandular growth patterns

♂ • tumors show local microinvasion as well as invasion to distant sites in the urogenital system such as the seminal vesicle

increased prostate intraepithelial neoplasia incidence ( J:103408 )

♂ • onset of mPIN is accelerated compared to single transgenic Tg(Pbsn-TAg)15Tvd mice, most likely due to a reduction in apoptosis

♂ • mPIN lesions increase in severity with age

abnormal prostate gland physiology ( J:103408 )

♂ • epithelial proliferation in the prostate remains similar to single transgenic Tg(Pbsn-TAg)15Tvd mice

♂ • apoptosis in the prostate is reduced compared to single transgenic Tg(Pbsn-TAg)15Tvd mice

neoplasm

increased prostate gland tumor incidence ( J:103408 )

♂ • onset of lesions is accelerated compared to single transgenic Tg(Pbsn-TAg)15Tvd mice; by 8 weeks of age, mutant prostates show pronounced cribriform and tufting of epithelial cells that are not seen until 12 weeks of age in single transgenic Tg(Pbsn-TAg)15Tvd mice

increased prostate gland adenocarcinoma incidence ( J:103408 )

♂ • onset of adenocarcinoma is accelerated compared to single transgenic Tg(Pbsn-TAg)15Tvd mice, most likely due to a reduction in apoptosis

♂ • some prostate abnormalities are different than in single transgenic Tg(Pbsn-TAg)15Tvd mice; pale cell carcinomas appear at around 17 weeks of age as do large focal adenocarcinomas with abundant cytoplasm and abnormal glandular growth patterns

♂ • tumors show local microinvasion as well as invasion to distant sites in the urogenital system such as the seminal vesicle

increased prostate intraepithelial neoplasia incidence ( J:103408 )

♂ • onset of mPIN is accelerated compared to single transgenic Tg(Pbsn-TAg)15Tvd mice, most likely due to a reduction in apoptosis

♂ • mPIN lesions increase in severity with age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
prostate cancer		DOID:10283	OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959	J:103408