Phenotypes Associated with This Genotype

Genotype
MGI:4836536

• Allelic Composition: Ncor2^{Gt(RRM275)Byg}/Ncor2⁺
• Genetic Background: B6.129P2-Ncor2^{Gt(RRM275)Byg}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

High fat diet-fed Ncor2^{Gt(RRM275)Byg}/Ncor2⁺ mice exhibit reduced hepatic steatosis

homeostasis/metabolism

decreased energy expenditure ( J:164558 )

• when fed a high fat diet, particularly during the dark phase

increased susceptibility to diet-induced obesity ( J:164558 )

• when fed a high fat diet

decreased carbon dioxide production ( J:164558 )

• when fed a high fat diet

decreased oxygen consumption ( J:164558 )

• when fed a high fat diet

increased insulin sensitivity ( J:164558 )

• when fed a high fat diet, mice exhibit protection from diet-induced insulin resistance due to improved adipocyte insulin sensitivity compared to in similarly treated wild-type mice

abnormal hormone level ( J:164558 )

• adipocyte leptin expression is decreased compared to in wild-type mice

decreased circulating insulin level ( J:164558 )

• at 3 months, mice fed a high fat diet exhibit decreased serum insulin levels following intraperitoneal injection with a bolus of glucose compared with similarly treated wild-type mice

decreased circulating leptin level ( J:164558 )

• in mice fed a high fat diet

adipose tissue

increased white adipose tissue amount ( J:164558 )

• when fed regular chow or a high fat diet

increased white fat cell number ( J:164558 )

• in the subcutaneous adipose tissue of mice fed a high fat diet

decreased white fat cell size ( J:164558 )

• in the subcutaneous adipose tissue of mice fed a high fat diet

abnormal white adipose tissue physiology ( J:164558 )

• when fed a high fat diet, adipocytes from epididymal and subcutaneous white adipose tissue exhibit improved insulin sensitivity compared to in similarly treated wild-type mice

• subcutaneous and epididymal adipocytes from mice fed a high fat diet exhibit increased insulin-induced suppression of lipolysis compared with cells from similarly treated wild-type mice

• subcutaneous adipocytes from mice fed a high fat diet exhibit increased isoproterenol-induced and insulin-suppressed free fatty acid release compared to cells from similarly treated wild-type mice

• however, epididymal adipocytes from mice fed a high fat diet exhibit normal isoproterenol-induced and insulin-suppressed free fatty acid release

cellular

abnormal cell differentiation ( J:164558 )

• mouse embryonic fibroblasts exhibit increased ability to differentiate into mature adipocytes compared with similarly treated wild-type cells

growth/size/body

increased susceptibility to diet-induced obesity ( J:164558 )

• when fed a high fat diet

behavior/neurological

abnormal eating behavior ( J:164558 )

• when fed a high fat diet

liver/biliary system

decreased susceptibility to diet-induced hepatic steatosis ( J:164558 )

• when fed a high fat diet