Phenotypes Associated with This Genotype

Genotype
MGI:4836591

• Allelic Composition: Kras^tm4Tyj/Kras⁺
• Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * C3H/HeJ)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal ovary morphology ( J:96296 )

♀ • after ovarian intrabursal injection of an adenovirus expressing Cre, mutants develop benign ovarian endometriosis-like lesions, however no invasive ovarian tumors are seen up to 10 months following adenoviral injection

growth/size/body

abnormal peritoneum morphology ( J:96296 )

• 47% of mutants develop peritoneal endometriosis following ovarian intrabursal injection of an adenovirus expressing Cre

• however, mice injected with adenovirus expressing Cre directly into the peritoneum do not develop peritoneal endometriosis

reproductive system

abnormal ovary morphology ( J:96296 )

♀ • after ovarian intrabursal injection of an adenovirus expressing Cre, mutants develop benign ovarian endometriosis-like lesions, however no invasive ovarian tumors are seen up to 10 months following adenoviral injection

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
endometriosis		DOID:289		J:96296