Phenotypes Associated with This Genotype

Genotype
MGI:4836596

• Allelic Composition: Kras^tm4Tyj/Kras⁺; Pten^tm1Hwu/Pten^tm1Hwu
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:96296 )

• survival of majority of mice is 10-20 weeks after intrabursal injection of an adenovirus expressing Cre

neoplasm

increased metastatic potential ( J:96296 )

• 43% of ovarian tumors metastasize to the lungs

increased endometrial carcinoma incidence ( J:96296 )

♀ • 7 weeks after intrabursal injection through the infundibulum of an adenovirus expressing Cre, mice, mutants develop endometrioid ovarian cancer

♀ • primary tumor is located in the ovary

♀ • tumors are solid and cystic and diagnosed as ovarian edometrioid adenocarcinomas

reproductive system

increased endometrial carcinoma incidence ( J:96296 )

♀ • 7 weeks after intrabursal injection through the infundibulum of an adenovirus expressing Cre, mice, mutants develop endometrioid ovarian cancer

♀ • primary tumor is located in the ovary

♀ • tumors are solid and cystic and diagnosed as ovarian edometrioid adenocarcinomas

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
ovarian cancer		DOID:2394	OMIM:167000 OMIM:607893	J:96296