Analysis Tools
digestive/alimentary system
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• mice develop multiple polyps in the small intestine one month after completion of pIpC injection to induce Cre expression
• polyps show a large excess of crypt-like units at their base and aberrant positioning of crypts along the edges of villi
• overgrowth and insertions of stromal cells from the base of the polypoid mass are seen in the small intestine one month after completion of pIpC injection to induce Cre expression
• intestinal stem cells exhibit increased proliferation due to Akt activation and nuclear localization of beta-catenin resulting in an increase of intestinal stem cells in the crypts
• these excess stem cells initiate de novo crypt formation and crypt fission at a higher rate than in controls
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neoplasm
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• mice injected with pIpC to induce Pten deletion, develop myeloproliferative disease and T-cell acute lymphoblastic leukemia
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immune system
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• mice injected with pIpC to induce Pten deletion have an enlarged thymus
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• mice injected with pIpC to induce Pten deletion have an enlarged spleen
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mortality/aging
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• mean survival time of mice injected with pIpC to induce Pten deletion is 35 days
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hematopoietic system
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• mice injected with pIpC to induce Pten deletion have an enlarged thymus
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• mice injected with pIpC to induce Pten deletion have an enlarged spleen
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endocrine/exocrine glands
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• mice injected with pIpC to induce Pten deletion have an enlarged thymus
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growth/size/body
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• mice injected with pIpC to induce Pten deletion have an enlarged spleen
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| acute lymphoblastic leukemia | DOID:9952 |
OMIM:247640 OMIM:613065 |
J:169097 | |
| Cowden syndrome | DOID:6457 |
OMIM:PS158350 |
J:118329 | |
